Dermo-cosmetic applications (Hygiene and skincare):

Smartest and safest skin cleansing system
(respects skin's natural pH value as well as optimizes skin microbiota)

Restores the cutaneous barrier, strenghtens the skin

Purifying, anti-pollution effect 

Reduces skin imperfections

Promotes cellular regeneration (anti-ageing) 


Woundcare / OTC applications:

Woudcare (woundwash, ulcers, burns)

Dermal (acne, atopic dermatitis, irritaded skin)

Oralcare (mouthwash, preventive and supportive in case of parodontosis/gingivitis' treatments.
Teeth's biofilm & tartar removing)

ORL (nasal spray / lavage, ear wash (cerumen))

Haemorrhoids (pain relief, healing, anti-bleeding)


 Smart Water

Discover water you never imagined before...

Whether in cosmetic or healthcare markets, consumers' believes have radically changed: they will definitely go for products ensuring

  • Proven efficacy
  • Naturally based
  • No side effects

At the cutting edge of high-performance skin care, Advanced Water S-100 is a breakthrough technology with a unique blend of essential natural minerals, to deliver proven, visible results as soon as it touches the skin’s surface. Advanced Water S-100 creates a natural defence for the skin, simultaneously reducing inflammation and detoxifying epidermal build-up from environmental aggressors whilst the high levels of replenishing minerals kick-start repair and stimulate regeneration.

Advanced Water S-100 acts both as an active ingredient and excipient thanks to its minerals and safe basicity. It opens plenty of new opportunities in dermo-cosmetics and OTC products' application fields and is totally in line with today challenges.



Unique active water
High degree of efficacy
A new way of formulating

Better performances - unique mechanisms of action.

Advanced Water S-100 combines both an excipient and an active component, ensuring unique efficacy and top safety for cosmetic & skin repair, such as skincare and cleansing, dermo-cosmetic, as well as a supportive therapy for wounds, burns, atopic dermatitis, acne, (...). Try it. Amazing.

Pure formulation without compromises

Advanced Water S-100 reshapes the way you develop and design innovative products thanks to its unique power. As Advanced Water only (diluted) or in combination with a few ingredients. Due to its preservative action, it redefines a new generation of pure and preservative-free products.

Easy to operate and efficient

Advanced Water S-100 simplifies technical constraints thanks to its unique self-preservative properties and light formula approach.


 Fascinating Nature


Water and minerals: the chemistry of life

If you thought water was a simple, innocent molecule, think again. Water is from far one of the most fascinating substance on our planet. Water remains one the major mysteries of the Universe. It supports life like no other substance does as chemical reactions in all plants and animals take place in water medium, releasing or consuming water in their metabolism. Life on Earth totally depends on water as living organisms are largely composed of water – about 70 to 90 percent by weight, and above 99 percent by absolute number of water molecules.

Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic life processes. Without water, these particular metabolic processes could not exist. Most of chemical reactions occur in the cell itself. Water plays a central role in biological and chemical, especially acid-base, processes. Equally important to our comprehension of the structure and dynamics of water is understanding the role it plays as a solvent facilitating long-ranged charge transport of species such as ions, excess protons and hydroxide ions. The excess proton and hydroxide ion, both particularly important in acid-base chemistry and bio-molecular function, plays an important role in the metabolism of all organisms as reflected by the wide variety of chemical reactions in which they take part. Ions are cofactors of enzymes, catalyzing basic functions such as electron transport, redox reactions, and energy metabolism; they are essential for maintaining the osmotic pressure of cells too.


Water, the universal solvent

Water is often referred to as the universal, superb solvent. Mainly due to the marked polarity of the water molecule and its tendency to form hydrogen bonds with other molecules. All of the components in cells (proteins, DNA and polysaccharides) are dissolved in water deriving their structure and activity from their interactions with water. Water dissolves more substances in greater quantities than any other common liquid making water key important in chemical, physical and biological processes.


Oxidation-reduction reactions

Basically, reduction means the addition of an election (e-), and its converse, oxidation means the removal of an electron. The addition of an electron, stores energy in the reduced compound. The removal of an electron, liberates energy from the oxidized compound. Whenever one substance is reduced, another is oxidized. In biological systems, removal or addition of an electron constitutes the most frequent mechanism of oxidation-reduction reactions, frequently called redox reactions.


Water is an acid and a base

Water can be both an acid and a base, depending on how you look at it. Water can even react with itself to form acid and bases. It happens in really small amounts; chemists have determined the concentration of H3O+ at 25°C as being very low: only a few molecules per billion will be dissociated. Dissociation of water forms an acid that increases the concentration of hydrogen ions (hydronium H3O+ also known as hydrated H+) and a base that increases the concentration of hydroxide ions (OH-). This can be amplified by using electrolysis process to drive an otherwise non-spontaneous chemical reaction.

The degree of acidity or alkalinity of a solution is measured in terms of a value known as pH, which is the negative logarithm of the concentration of hydrogen ions. Scientists have defined a pH scale which ranges from 0 on the acidic end to 14 on the alkaline end, a neutral solution being at pH 7. At pH 7 water contains equal concentrations of H+ and OH- ions. Substances with pH higher than 7 are alkaline as having a higher concentration of OH- than H+ and vice versa for acidic substance with pH lower than 7 containing a higher concentration of H+ than OH-. The pH scale is a log scale so a change of 1 pH units means a tenfold change in the concentration of hydrogen ions.


pH and chemistry: avoid misunderstanding

Be aware that high or low pH does not necessarily means that a product is corrosive or not. Do not mistake pH and chemistry. pH is defined by hydrogen ions. pH meter device estimates the amount of hydrogen (H3O+) passing through the glass membrane from the electrode potential value. In other words, pH meter does not directly measure hydrogen ion concentration. The number displayed by pH meter is the value converted from electrode potential to pH.

You can drink Cola which has a pH of 2-3 (weak acid) but any student having knowledge in chemistry knows well that we cannot drink any solution of a strong acid (such as hydrochloric acid) at the same pH value, which would definitely create a problem... The same for high pH. In other words, we cannot judge if a product is safe or not solely by its pH. The same for lemon which is very acidic; but turns to alkaline once ingested. Important is to look at the reaction's behavior and the reaction which is generated.

Advanced Water S-100 is the most innovative water in the world in terms of mineralization, pH and biocompatibility: once in contact with human skin and its organic acids, pH is quickly neutralized to natural skin's pH level.

Did you know?

Ashes when mixed with rainwater ends up in a very high and safe pH of about 11. Wood ashes are not toxic; combined to rainwater or demineralized water, its high pH stimulates the growth of plants, as we can observe after wild fires, where new plants quickly emerge from a burned soil covered with ashes.
This is the magic of nature.

When grass and trees benefit

Wood ashes offer significant potassium, but their greatest potential benefit to lawns comes from alkalinity (high pH). Thes ashes have properties similar to lime products used to raise soil pH. For example, lawn grasses generally prefer slightly acidic soil in the 6.0 to 7.0 pH range, but high-fertilizers tend to lower soil pH over time. Many countries have naturally acidic soil. When soil pH drops below 6.0, it limits the ability of plants to take up essential nutriments, including nitrogen, phosphorus and iron. Lawn beauty, health and resilience suffer. If your soil is acidic or potassium-deficient, wood ashes can help your grass to grow.


 Advanced Water Technology


Ionized reduced water

Alkaline ionized water generated by water electrolysis has constantly received increasing attention due to benefits in treatment and prevention of diseases. Electrolysis of slightly salt water or tap water produces a special water very useful and known as functional electrolyzed water. Various types of functional water can be produced depending on conditions of electrolysis, and these types of water are classified into two major categories. One is functional electrolyzed acidic water, which is generated at the anode; the other one, generated at the cathode, is electrolyzed alkaline water. Both, depending on their properties, are widely used in medical, cosmetic and technical fields.

In Japan, research on functional water, especially on electrochemically reduced water (ERW) also known as electrochemically reduced alkaline water (ERAW), is developing at a rapid pace.

Studies on the functions of ERW were initiated in Japan in the 40’s and its application to agriculture was first attempted in 1954. Six years later, the Ministry of Health, Labor and Welfare of Japan, admitted ERW as effective for human health against various diseases (external & internal) and authorized ERW producing devices as Medical Device. Korean Food & Drug Administration (KFDA) followed a few years later. Today fast accumulating evidences demonstrate how ERW can be health beneficial and active in reducing oxidative stress-related diseases.     


Advanced Water S-100

ADWATIS SA provides a new generation of ionized water, Advanced Water S-100, totally different from all other traditional alkaline ones:

  • Unequalled, 100% safe and non-chemical ionized mineralized water.
  • Unique properties due to mineralization combined with high pH and very low basicity.
  • Patented JP2007050400

Environmentally friendly and safe manufacturing process

Ionized water S-100 is made out of innovative electrolytic patented process as well as longstanding expertise and know-how. Having a pH of 12, it has about 100’000 times more negative ions than normal water (approx. pH 7). Advanced Water S-100 is stable and effective for 3-4 years. It can be diluted with water or mixed under certain conditions with other ingredients while maintaining ionic properties. 

The production process of Advanced Water S-100 is totally safe, clean and without any negative impact on the environment. The by-product generated by the electrolytic process, i.e. the acidic water in the anode chamber, has a very low hydrochloric acid content which is neutralized and then eliminated, without any chlorine emanation. Our policy is to take into account not only the security of human life, but also the security of the environment.


Advanced Water S-100 is unique

It consists in a unique mineralization with high reducibility and semi-permanent stability caused by molecular ions with electron rich state. These molecular ions are characterized as high pH and weak basicity according to Lewis theory.
This means that pH of Advanced Water S-100 is not defined by the concentration of hydrogen ions or hydroxide ions but by electrons according to Lewis' theory. Therefore, Advanced Water S-100 is totally safe and 100% biocompatible with human skin thanks to very weak basicity and specific minerals, providing a unique optimization of cell's and tissues' ionic balance and metabolism.

Advanced Water S-100

Standard alkaline waters

  • pH 12, mineralized, slightly negative ORP, bio-compatible, with high reduction properties *)
  • pH 9-10, ORP up to -600/-700mV
  • Stable (over 3 years)
  • Very unstable, quick loss of reduction power and basicity
  • Stable and safe properties thanks to a unique manufacturing process.

  • Made out of pure and ultra-filtered water enriched with selected minerals (Na, Si, K, P, Mg, Ca, Cl).

  • Can be diluted with demineralized water while maintaining ionic properties.

  • Advanced Water is a weak base. It is equivalent to 0,04M NH4OH.

  • When in contact with the skin and its organic acids, Advanced Water S-100 is quicly neutralized to skin's natural pH level.

  • Unstable ionic properties which will even vary depending on production process. 

  • Made out of standard tap water without any control on mineral salts.

  • Potential presence of strong bases such as NaOH or KOH (toxic). Temporariliy presence of Hydrogen (H2).

  • Revert to neutral when diluted.

  • Does not keep ionic properties.

*) The ORP method according to the classical formula is not sufficient to fill in the redox of Advanced Water S-100. Indeed, the redox-meter cannot measure the value at the electrode interface at the nanoscale, so the measured value does not represent the redox power at the reaction interface in the case of a complexe electrolyte such as S-100. The most powerful analytical technique is based on electrochemistry where the resistance of the sample to be oxidized is translated to antioxidant capacity and expressed in µmol (ascorbic acid) vitamin C such as CEAC or BAP. Advanced Water S-100 and derivated formulations have high antioxidant  capacity values.



Unique mechanisms of action

Basic principle: S-100 Water contains negative ions OH-. Once in contact with any kind of surface, material, particles, water ions interact by reorganizing electric charges. The surface remains polarized and actively prevents from any future building up of foreign particles, (known as "Double electric layer" theory).


1. The smartest cleansing system ever

Advanced Water S-100, with its army of negatively charged ions, penetrates, encapsulates all kind of particles such as atoms, molecules, micro-organisms, (...) and removes them by repulsion effect (due to same polarity) from all kind of even or uneven microscopic surfaces. Isolated particles and pollutants are easily removed by rinsing. In case of dermo-cosmetic applications, the same mechanism happens: e.g. skin cleansing where ionic work force interacts between lipids (sebum) and skin, producing a so-called repulsion force effect.


Comparison made with "Micellar Water make-up remover" (left) versus Advanced Water S-100 (30% dilution) (right). Drawing made on a tile using "edding 250 whiteboard marker".


2. Antimicrobial & Preservative power



In case of surface bacterial contamination such as E-coli, the ionization process of Advanced Water S-100, depending on dilution rate, quickly polarizes and dislodges the bacteria. Bacteria outer membrane (Gram-) is dissolved by ions force, leading rapidly to the destruction of the cell nucleus, eliminating any chance of re-contamination. Gram+ type bacteria are quickly dislodged by repulsion force. In any case, Advanced Water is definitely not a biocide and not classified as a bactericide.


Advanced Water S-100 is the most innovative water in the world in terms of noble mineralization, low basicity and biocompatibility.



Bacteria, even alkaliphilic bacteria which are comfortable with high pH, cannot survive in pH over 10.5. Bacteria growth is therefore impossible under S-100 high pH (11.5 – 12.5). When in contact with the skin and its organic acids, Advanced Water S-100 is quicly neutralized to skin's natural pH level; in any case, absolutely no negative reaction/stimulation of the skin is observed, as confirmed by several tests and analysis made by well-known European laboratories and research centers, such as:

  • Patch test 48 hours: non irritant
  • Human elbow fold test: very good skin compatibility
  • Challenge Test: A Criteria (pure) / B Criteria (diluted)
  • Cutaneous/Ocular Safety & Efficiency Assessment (Dermscan / clinical study):
    - Restores the cutaneous barrier
      (anti-fatigue & brightening effect, more uniformed skin complexion, less visible pores, soothing effect).
    - Strengthens the skin
    - Skin protection

  • TEWL (Transepidermal Water Loss): significant reduction
  • Cleansing against particles: anti-pollution effect
  • Eye test Het cam: slightly irritant (3)
  • Stratum corneum test: 100% safe
  • Proton mobility: very high (2700ms)


3. Cell's ionic balancing and regeneration

Advanced Water S-100 combines both effects of its high pH and unique mineralization (Na, Si, K, P, Mg, Ca, Cl), structured through a patented electrolytic process, generating unique molecular compositions. Advanced Water not only cleans, protects and ensures stressed/damaged skin's pH balance but also plays a key role in supporting cellular's functioning and regeneration (metabolism and ionic balance).

Thanks to an adequate pH and minerals environement, cells can develop and accelerate healing process by reducing inflammation and stimulating vascularization. Combined with its anti-microbial and cleansing effects, Advanced Water S-100 offers a state of the art solution for skincare and woundcare (e.g. burn, ulcers, atopic dermatits, damaged or stressed skin)..


100% biocompatible

Thanks to its weak basicity (equivalent to 0,04M NH4OH) Advanced Water S-100 does show respect for natural skin pH as being quicky neutralized when in contact with its natural organic acids. It easily penetrates the different skin's layers without damaging cell's membrane and cutaneous microbiote, unlike surfactants, alcohol, preservatives (...) which presence in most of today cosmetic/OTC formulas seriously denature and damage skin's tissues.

The microbiota of the skin is very important as a protective mechanism; the microorganisms that live on and in human skin and their diversity contribute in balancing the microbita, which characterizes an healthy skin.  It should be noted that dead bacteria must be evacuated in order to elminate their toxins, especially for staphylococcus. The action of diluted Advanced Water S-100 on the skin helps to cleanse and maintain an healthy microbiota thanks to its anti-microbial effect using electric charges, mainly against Gram- bacteria. Skin-resident bacteria Gram+ are partially dislodged by repulsion charge -/- thanks to negatively charged outer membrane due to teichoic acid.

Advanced Water is the only safe and original high pH water without any chemicals or harmful ingredients.


 Products & Applications


Advanced Water S-100

combines both an excipient and an active component. It opens a new generation of unequally pure and innovative products in cosmetic and OTC pharma with high performance and unique mechanisms of action:

  • Smartest Cleansing system ever
  • Antibacterial / Preservative Power
  • Cellular regeneration Power


Advanced Water S-100 is made out of highly purified water and 7 key minerals:

  • Sodium and Potassium are the moste important ions for outside / inside the cell.
  • Phosphorus as a key role in autophagy process / immune function. It is an essential mineral for almost all chemical reactions inside the cells.
  • Silicon due to its 4 legs structure can create a myriad of substances. These substances are essential in cell's repairing and regenerating processes. Advanced Water S-100 has many different silicon molecular structures. Silicon stimulates the formation of collagen's fibers, which is especially indicated in order to tone and firm the skin.
  • Calcium and Magnesium are essential elemens in the metabolism of eukaryotic cell biology. Magnesium as en enzymatic activator as well as calcium as intra-cell regulator.
  • Chlorides generated make sodium and potassium stable and safe.


Having a pH of 12 - totally safe an nontoxic - Advanced Water S-100 creates an environment which is incompatible with bacteria and virus. Advanced Water S-100 is a weak base and is equivalent to 0,04M of NH4OH in terms of basicity, which makes it totally safe and non aggressive. When in contact with the skin and its organic acids, Advanced Water S-100 is quickly neutralized to skin's natural pH level.

Advanced Water S-100 is totally stable overs years and can be mixed, under certain conditions, in case of "light" formulas, with other products as long as pH remains over 11.00 once stability tests have been completed.

Advanced Water GEL CC6

is a light viscous water gel based on S-100 wth identical properties. Can be easily obtained by mixing S-100 Water with 1% CMC Sodium Carboxymethyl Cellulose.


Application's fields


Dermo-Cosmetic (skincare and hygiene)

As a waterspray S-100, watergel CC6, lotion, cream or serum:

  • Smartest and safest skin cleansing system (respects skin's natural pH value as well as optimizes skin microbiote)
  • Restores the cutaneous barrier, strenghtens the skin
  • Purifying, anti-pollution effect 
  • Reduces skin imperfections
  • Promotes cellular regeneration (anti-ageing)     >>>> See detailed Advice for use


Formulation for Dermo-Cosmetic



Thanks to our GAPP Partnership, the French company PB Group / Sudcosmetics ( can provide you with a range of high pH cosmetic products, especially developped with Advanced Water S-100 and its unique properties for more efficacy and without any preservative thanks to S-100 power.

  • Detox Cleaning Foam

  • Micellar Active Water

  • Leave-on Hand Cleansing Gel

  • Milky Mist

  • Cream (face & body)

  • Jelly Scrub

and more...


You can have access to the original S-100 Presentation for dermo-cosmetic made by our GAPP Partner, the company PB Group, by clicking the below link:




OTC Medical  / Veterinary


As waterspray S-100, watergel CC6 for:

  • Woudcare (woundwash, ulcers, burns)
  • Dermal (acne, atopic dermatitis, irritaded skin)
  • Oralcare (mouthwash, preventive and supportive in case of parodontosis/gingivitis' treatments, teeth's biofilm & tartar removing)
  • ORL (oralcare, nasal lavage, ear wash (cerumen))
  • Haemorrhoids (pain relief, healing, anti-bleeding)


Examples of clinical cases for burn, wound & dermal

Extracts from single cases (over 1000 cases as of today) and clinical cases' studies. Scientific papers under section "Scientific papers / Tests".

  • Cleaning and detoxifying of open wounds

  • Moisturizing to better support scarring process

  • Healing to prevent infection

  • Restoring of tissue and skin functions.








Formulation for OTC Medical





Advanced Water Packaging size & content


  • Advanced Water S-100: Available in 18 liters bag-in-box (PE inner bag with plastic tap)
    Bag-in-box size: 300mm*300mm*280mm
    Eur-pallet (EPAL): 8 boxes/layer - max 4 layers: total 32 boxes equivalent to 576 liters

    Advanced Water S-100 Commodity Code: 2201.1000

  • Advanced Water Gel CC6: Available for sampling (1 liter)
 Tech Data / Leaflets / Advice for use

Technical Data and Specifications





Medical / Clinical cases


Advice for use


ADWATIS SA  |  Boucle de Cydalise 1  |  2300 La Chaux-de-Fonds  |  Switzerland
Boucle de Cydalise 1
2300 La Chaux-de-Fonds